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Article

Exploring the Effects of Intersubunit Interface Mutations on Virus-Like Particle Structure and Stability.

Biochemistry - 6 Aug 2024

Pistono Paige E, Xu Junyi, Huang Paul, Fetzer Jennifer L, Francis Matthew B

Abstract excerpt

Virus-like particles (VLPs) from bacteriophage MS2 provide a platform to study protein self-assembly and create engineered systems for drug delivery. Here, we aim to understand the impact of intersubunit interface mutations on the local and global structure and function of MS2-based VLPs. In previous work, our lab identified locally supercharged double mutants [T71K/G73R] that concentrate positive charge at...

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Identifiers

PMID: 39037053
DOI: 10.1021/acs.biochem.4c00225
PMCID: PMC11308365

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