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Article

Assessing sequence plasticity of a virus-like nanoparticle by evolution toward a versatile scaffold for vaccines and drug delivery.

Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2015

Lu Yuan, Chan Wei, Ko Benjamin Y, VanLang Christopher C, Swartz James R

Abstract excerpt

Virus-like particles (VLPs) have been extensively explored as nanoparticle vehicles for many applications in biotechnology (e.g., vaccines, drug delivery, imaging agents, biocatalysts). However, amino acid sequence plasticity relative to subunit expression and nanoparticle assembly has not been explored. Whereas the hepatitis B core protein (HBc) VLP appears to be the most promising model for fundamental and...

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Identifiers

PMID: 26392546
DOI: 10.1073/pnas.1510533112
PMCID: PMC4603490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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