Article
The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum.
PloS one - 1 Jan 2013
Cohen Yifat, Megyeri Márton, Chen Oscar C W, Condomitti Giuseppe, Riezman Isabelle, Loizides-Mangold Ursula, Abdul-Sada Alaa, Rimon Nitzan, Riezman Howard, Platt Frances M, Futerman Anthony H, Schuldiner Maya
Abstract excerpt
The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite intense research, the function of more than a third of ER proteins remains unknown even in the well-studied model organism Saccharomyces cerevisiae. One such protein is Spf1, which is a highly conserved, ER localized, putative P-type ATPase. Deletion of SPF1 causes a wide variety of phenotypes including severe ER stress...
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