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Next-Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma

27 Feb 2018

Abstract excerpt

Abstract Background Because imaging has a high sensitivity to diagnose hepatocellular carcinoma (HCC) and tissue biopsies carry risks such as bleeding, the latter are often not performed in HCC. Blood-derived circulating tumor DNA (ctDNA) analysis can identify somatic alterations, but its utility has not been characterized in HCC. Materials and Methods We evaluated 14 patients with advanced HCC (digital ctDNA...

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Identifiers

PMID: 29487225
DOI: 10.1634/theoncologist.2017-0479

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