Article
A Comprehensive Analysis of Nuclear-Encoded Mitochondrial Genes in Schizophrenia.
Biological psychiatry - 1 May 2018
Gonçalves Vanessa F, Cappi Carolina, Hagen Christian M, Sequeira Adolfo, Vawter Marquis P, Derkach Andriy, Zai Clement C, Hedley Paula L, Bybjerg-Grauholm Jonas, Pouget Jennie G, Cuperfain Ari B, Sullivan Patrick F, Christiansen Michael, Kennedy James L, Sun Lei
Abstract excerpt
BACKGROUND: The genetic risk factors of schizophrenia (SCZ), a severe psychiatric disorder, are not yet fully understood. Multiple lines of evidence suggest that mitochondrial dysfunction may play a role in SCZ, but comprehensive association studies are lacking. We hypothesized that variants in nuclear-encoded mitochondrial genes influence susceptibility to SCZ. METHODS: We conducted gene-based and gene-set...
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