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Article

Individualized phenytoin therapy for Japanese pediatric patients with epilepsy based on CYP2C9 and CYP2C19 genotypes.

Therapeutic drug monitoring - 1 Apr 2015

Yamamoto Yoshiaki, Takahashi Yukitoshi, Imai Katsumi, Miyakawa Kou, Ikeda Hiroko, Ueda Yuki, Yamaguchi Tokito, Nasu Hirosato, Ohtani Hideyuki, Shigematsu Hideo, Kagawa Yoshiyuki, Inoue Yushi

Abstract excerpt

BACKGROUND: The aims of this study were to identify the target dose of phenytoin (PHT) and to compare the treatment continuation rate between patients receiving conventional therapy and patients receiving individualized therapy based on genotyping of the CYP2C9*3, CYP2C19*2, and CYP2C19*3 alleles. The operational definition for the target dose of PHT used in this study was the dose that yielded a steady-state PHT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Source

Identifiers

PMID: 25162219
DOI: 10.1097/FTD.0000000000000128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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