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Article

Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS.

Neurobiology of disease - 1 Jul 2018

Riehm Jacob J, Wang Lijun, Ghadge Ghanashyam, Teng Michael, Correa Ana M, Marks Jeremy D, Roos Raymond P, Allen Michael J

Abstract excerpt

Here we report a gain in function for mutant (mt) superoxide dismutase I (SOD1), a cause of familial amyotrophic lateral sclerosis (FALS), wherein small soluble oligomers of mtSOD1 acquire a membrane toxicity. Phosphatidylglycerol (PG) lipid domains are selectively targeted, which could result in membrane damage or "toxic channels" becoming active in the bilayer. This PG-selective SOD1-mediated membrane toxicity...

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Identifiers

PMID: 29627580
DOI: 10.1016/j.nbd.2018.03.014
PMCID: PMC5943144

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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