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Article

Disruption of mitochondrial membrane integrity induced by amyloid aggregates arising from variants of SOD1.

International journal of biological macromolecules - 1 Oct 2013

Oladzad Abbasabadi Azarakhsh, Javanian Asyeh, Nikkhah Maryam, Meratan Ali Akbar, Ghiasi Parisa, Nemat-Gorgani Mohsen

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder selectively affecting motor neurons; 90% of the total cases are sporadic, but 2% are associated with mutations in the gene coding for copper-zinc superoxide dismutase (SOD1). The causes of motor neuron death in ALS are poorly understood in general, but for SOD1-linked familial ALS (fALS), aberrant oligomerization of SOD1 mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23872456
DOI: 10.1016/j.ijbiomac.2013.07.007

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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