Article
Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS).
PloS one - 8 Mar 2010
Stevens James C, Chia Ruth, Hendriks William T, Bros-Facer Virginie, van Minnen Jan, Martin Joanne E, Jackson Graham S, Greensmith Linda, Schiavo Giampietro, Fisher Elizabeth M C
Abstract excerpt
BACKGROUND: Since the discovery that mutations in the enzyme SOD1 are causative in human amyotrophic lateral sclerosis (ALS), many strategies have been employed to elucidate the toxic properties of this ubiquitously expressed mutant protein, including the generation of GFP-SOD1 chimaeric proteins for studies in protein localization by direct visualization using fluorescence microscopy. However, little is known...
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