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Article

A liquid-to-solid phase transition of Cu/Zn superoxide dismutase 1 initiated by oxidation and disease mutation.

The Journal of biological chemistry - 1 Feb 2023

Gu Siyu, Xu Ming, Chen Long, Shi Xiangyan, Luo Shi-Zhong

Abstract excerpt

Cu/Zn superoxide dismutase 1 (SOD1) has a high propensity to misfold and form abnormal aggregates when it is subjected to oxidative stress or carries mutations associated with amyotrophic lateral sclerosis. However, the transition from functional soluble SOD1 protein to aggregated SOD1 protein is not completely clear. Here, we propose that liquid-liquid phase separation (LLPS) represents a biophysical process...

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Identifiers

PMID: 36592929
DOI: 10.1016/j.jbc.2022.102857
PMCID: PMC9898760

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