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Article

SOCS2 inhibits hepatoblastoma metastasis via downregulation of the JAK2/STAT5 signal pathway

9 Dec 2023

Abstract excerpt

Metastasis of hepatoblastoma (HB) is a key factor that impairs the prognosis and treatment of children. The suppressor of cytokine signaling 2 (SOCS2) is a classical negative feedback protein that regulates cytokine signal transduction and has been known to be downregulated in several tumor, but the molecular mechanisms of its involvement in HB metastasis are unknown. We found that SOCS2 was a gene down-regulated...

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Cancer Mechanisms and Therapy
Cytokine Signaling Pathways and Interactions
PI3K/AKT/mTOR signaling in cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38071211
DOI: 10.1038/s41598-023-48591-7

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