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Article

HIV-1 Vpu restricts Fc-mediated effector functions in vivo

1 Nov 2022

Abstract excerpt

Non-neutralizing antibodies (nnAbs) can eliminate HIV-1-infected cells via antibody-dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the RV144 vaccine trial. Fc-mediated effector functions of nnAbs were recently shown to alter the course of HIV-1 infection in vivo using a vpu-defective virus. Since Vpu is known to downregulate cell-surface CD4, which triggers...

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PMID: 36351384
DOI: 10.1016/j.celrep.2022.111624

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