Article
HLA-G 5'URR regulatory polymorphisms are associated with the risk of developing gliomas.
The International journal of neuroscience - 1 Apr 2023
Durmanova Vladimira, Kluckova Kristina, Filova Barbora, Minarik Gabriel, Kozak Jan, Rychly Boris, Svajdler Marian, Matejcik Viktor, Steno Juraj, Bucova Maria
Abstract excerpt
BACKGROUND: Human leukocyte antigen G (HLA-G) belongs to non-classical MHC class I molecules that is involved in the suppression of immune response. As HLA-G plays important role in the maintenance of fetal tolerance, its overexpression has been associated with tumor progression. For the regulation of HLA-G levels, genetic variants within the 5' upstream regulatory region (5'URR) are of crucial importance. Our...
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