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Article

B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex

4 Apr 2018

Abstract excerpt

GARP, a cell surface docking receptor for binding and activating latent TGF-β, is highly expressed by platelets and activated Tregs. While GARP is implicated in immune invasion in cancer, the roles of the GARP-TGF-β axis in systemic autoimmune diseases are unknown. Although B cells do not express GARP at baseline, we found that the GARP-TGF-β complex is induced on activated human and mouse B cells by ligands for...

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PMID: 29618665
DOI: 10.1172/jci.insight.99863

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