Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015

Lacey Derek, Hickey Peter, Arhatari Benedicta D, O'Reilly Lorraine A, Rohrbeck Leona, Kiriazis Helen, Du Xiao-Jun, Bouillet Philippe

Abstract excerpt

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic inflammatory diseases that together affect 2-3% of the population. RA and AS predominantly involve joints, but heart disease is also a common feature in RA and AS patients. Here we have studied a new spontaneous mutation that c...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneurysm
Share to Arthritis
Share to Chemokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Valve Diseases

Share to Joints

Share to Mitral Valve

Share to Short Interspersed Nucleotide Elements

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 26195802
DOI: 10.1073/pnas.1508399112
PMCID: PMC4534232

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26195802-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis.PMID 26195802Read ↗

Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosisSemantic proximity Read ↗

Deregulation of TNF expression can also cause heart valve disease.Semantic proximity Read ↗

A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice.Semantic proximity Read ↗

Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse modelSemantic proximity Read ↗

Transcriptional control of the TNF gene.Semantic proximity Read ↗

The role of TNF and its family members in inflammation and cancer: lessons from gene deletion.Semantic proximity Read ↗

Direct evidence for the expression of multiple endogenous retroviruses in the synovial compartment in rheumatoid arthritisSemantic proximity Read ↗

Transgenic mice expressing a truncated Peromyscus leucopus TNF-alpha gene manifest an arthritis resembling ankylosing spondylitis.Semantic proximity Read ↗

The potential role of human endogenous retrovirus K10 in the pathogenesis of rheumatoid arthritis: a preliminary studySemantic proximity Read ↗

Human parvovirus B19 transgenic mice become susceptible to polyarthritis.Semantic proximity Read ↗

T2 open reading frame from the shope fibroma virus encodes a soluble form of the TNF receptorSemantic proximity Read ↗

A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.