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Article

Morphometric analysis of spread platelets identifies integrin αIIbβ3-specific contractile phenotype.

Scientific reports - 3 Apr 2018

Lickert Sebastian, Sorrentino Simona, Studt Jan-Dirk, Medalia Ohad, Vogel Viola, Schoen Ingmar

Abstract excerpt

Haemostatic platelet function is intimately linked to cellular mechanics and cytoskeletal morphology. How cytoskeletal reorganizations give rise to a highly contractile phenotype that is necessary for clot contraction remains poorly understood. To elucidate this process in vitro, we developed a morphometric screen to quantify the spatial organization of actin fibres and vinculin adhesion sites in single spread...

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Identifiers

PMID: 29615672
DOI: 10.1038/s41598-018-23684-w
PMCID: PMC5882949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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