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Article

Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the αIIbβ3 integrin.

Seminars in thrombosis and hemostasis - 1 Sept 2011

Nurden Alan T, Pillois Xavier, Fiore Mathieu, Heilig Roland, Nurden Paquita

Abstract excerpt

Glanzmann thrombasthenia (GT) is the most widely studied inherited disorder of platelets; it is caused by the absence of platelet aggregation due to quantitative and/or qualitative deficiencies of the αIIbβ3 integrin coded by the ITGA2B and ITGB3 genes located at 17q21-23. Although platelet count and platelet volume (and morphology) are normal in classic GT, some reports have inferred a role for αIIbβ3 in...

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Source

Identifiers

PMID: 22102273
DOI: 10.1055/s-0031-1291380

Genes

ITGB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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