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Megakaryocyte Cytoskeletal Proteins in Platelet Biogenesis and Diseases

4 Jul 2021

Abstract excerpt

Thrombopoiesis governs the formation of blood platelets in bone marrow by converting megakaryocytes into long, branched proplatelets on which individual platelets are assembled. The megakaryocyte cytoskeleton responds to multiple microenvironmental cues, including chemical and mechanical stimuli, sustaining the platelet shedding. During the megakaryocyte's life cycle, cytoskeletal networks organize cell shape and...

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PMID: 34218430
DOI: 10.1055/s-0041-1731717

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