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Beyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers

6 Nov 2025

Abstract excerpt

Immunotherapy has revolutionized hematologic cancer treatment, yet responses remain unpredictable due to primary resistance, relapse, and life-threatening toxicities. Conventional biomarkers fail to capture the complexity of tumor-immune interactions, necessitating integrative approaches. This review explores how multi-omics technologies, genomics, transcriptomics, proteomics, metabolomics, spatial omics, and...

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PMID: 41193778
DOI: 10.1007/s10238-025-01902-w

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