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Article

Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration

4 Apr 2018

Abstract excerpt

Aging is the strongest risk factor for neurodegenerative diseases and extended age results in neuronal degeneration and functional decline in the visual system. Among many contributing factors to age-related deterioration of neurons is an insufficient activation of the Unfolded Protein Response (UPR) in the endoplasmic reticulum (ER) in response to cellular stress. X-box binding protein 1 (XBP1) is a major...

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Share to Cellular transport and secretion
Share to Endoplasmic Reticulum Stress and Disease
Share to Retinal Diseases and Treatments

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PMID: 29615095
DOI: 10.1186/s13024-018-0250-z

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