Article
A mutation in Bicdl1 (BICD family-like cargo adaptor 1) leads to mild outer retina thinning and late retinal dysfunction in a mouse model.
Molecular vision - 1 Jan 2026
Ulker-Yilmazer Gizem, Kirman Dogan Can, Yu Tian, Turpin Emily R, Shrestha Sangita, Yuksel Seher, He Yu-Guang, Ludwig Sara, Kumar Ashwani, Xing Chao, Moresco Eva M Y, Beutler Bruce A, Aredo Bogale, Ufret-Vincenty Rafael L
Abstract excerpt
Purpose: Both photoreceptors and the retinal pigment epithelium (RPE) are highly metabolically active cell types that require extensive molecular transport and adequate energy production to maintain their function. We tested the hypothesis that cargo adaptor protein Bicdl1 has a non-redundant role in retinal health. Methods: Using an unbiased forward genetics approach, we identified an association between outer...
Read the complete abstract on PubMedTopics
- Animals
- Mice
- Retinal Pigment Epithelium
- Disease Models, Animal
- Electroretinography