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Article

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2015

Varea Olga, Martin-de-Saavedra Maria Dolores, Kopeikina Katherine J, Schürmann Britta, Fleming Hunter J, Fawcett-Patel Jessica M, Bach Anthony, Jang Seil, Peles Elior, Kim Eunjoon, Penzes Peter

Abstract excerpt

Central glutamatergic synapses and the molecular pathways that control them are emerging as common substrates in the pathogenesis of mental disorders. Genetic variation in the contactin associated protein-like 2 (CNTNAP2) gene, including copy number variations, exon deletions, truncations, single nucleotide variants, and polymorphisms have been associated with intellectual disability, epilepsy, schizophrenia,...

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Identifiers

PMID: 25918374
DOI: 10.1073/pnas.1423205112
PMCID: PMC4434727

Genes

CNTNAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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