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Article

H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation.

The Journal of biological chemistry - 18 May 2018

Huang Yaping, Gu Liya, Li Guo-Min

Abstract excerpt

Histone H3 trimethylation at lysine 36 (H3K36me3) is an important histone mark involved in both transcription elongation and DNA mismatch repair (MMR). It is known that H3K36me3 recruits the mismatch-recognition protein MutSα to replicating chromatin via its physical interaction with MutSα's PWWP domain, but the exact role of H3K36me3 in transcription is undefined. Using ChIP combined with whole-genome DNA...

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PMID: 29610279
DOI: 10.1074/jbc.RA118.002839
PMCID: PMC5961058

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