Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mismatch repair prefers exons.

Nature genetics - 29 Nov 2017

Massey Dashiell J, Koren Amnon

Abstract excerpt

A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mismatch Repair
Share to Exons
Share to Introns
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation Rate

Source

Identifiers

PMID: 29186127
DOI: 10.1038/ng.3993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mismatch repair prefers exons.PMID 29186127Read ↗

Reduced mutation rate in exons due to differential mismatch repair.Semantic proximity Read ↗

The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selectionSemantic proximity Read ↗

DNA mismatch repair preferentially protects genes from mutation.Semantic proximity Read ↗

Mismatch repair defects in cancerSemantic proximity Read ↗

A redefined InDel taxonomy provides insights into mutational signaturesSemantic proximity Read ↗

Differential DNA mismatch repair underlies mutation rate variation across the human genomeSemantic proximity Read ↗

Human DNA repair genes. Wood RD, Mitchell M, Sgouros J, Lindahl T. Science 2001;291:1284–1289.Semantic proximity Read ↗

Mutated tumor alleles are expressed according to their DNA frequency.Semantic proximity Read ↗

Depletion of somatic mutations in splicing-associated sequences in cancer genomes.Semantic proximity Read ↗

Switching off DNA repair-how colorectal cancer evades targeted therapies through adaptive mutability.Semantic proximity Read ↗

Summaries for patients. Mutations in DNA mismatch repair genes.Semantic proximity Read ↗

Eukaryotic mismatch repair: an updateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.