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Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression

21 Mar 2011

Abstract excerpt

BACKGROUND: Inappropriate cross talk between mammals and their gut microbiota may trigger intestinal inflammation and drive extra-intestinal immune-mediated diseases. Epithelial cells constitute the interface between gut microbiota and host tissue, and may regulate host responses to commensal enteric bacteria. Gnotobiotic animals represent a powerful approach to study bacterial-host interaction but are not...

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PMID: 21445311
DOI: 10.1371/journal.pone.0017996

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