Article
Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice.
Nature microbiology - 1 Feb 2018
Schulfer Anjelique F, Battaglia Thomas, Alvarez Yelina, Bijnens Luc, Ruiz Victoria E, Ho Melody, Robinson Serina, Ward Tonya, Cox Laura M, Rogers Arlin B, Knights Dan, Sartor R Balfour, Blaser Martin J
Abstract excerpt
Antibiotic exposure in children has been associated with the risk of inflammatory bowel disease (IBD). Antibiotic use in children or in their pregnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children could affect their risk of developing IBD. Here we demonstrate that germ-free adult pregnant mice...
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