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Article

Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal Bacteroides thetaiotaomicron

29 Jan 2025

Abstract excerpt

ABSTRACT In the gut, microRNAs (miRNAs) produced by intestinal epithelial cells are secreted into the lumen and can shape the composition and function of the gut microbiome. Crosstalk between gut microbes and the host plays a key role in irritable bowel syndrome (IBS) and inflammatory bowel diseases, yet little is known about how the miRNA–gut microbiome axis contributes to the pathogenesis of these conditions....

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PMID: 39878512
DOI: 10.1128/mbio.03928-24

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