Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA‐21 increases the expression level of occludin through regulating ROCK1 in prevention of intestinal barrier dysfunction

9 Oct 2018

Abstract excerpt

OBJECTIVE: The aim of this study is to investigate the role of molecular mechanism of microRNA (miR)-21 on tight junction (TJ)-proteins and its protective effects on the intestinal barrier. METHODS: TJ proteins and target genes expression were analyzed in miR-21 inhibition and overexpression NCM460 cell lines. To further verify the role of miR-21, the mmu-miR-21 intestinal epithelial conditional knockout (IKO)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barrier Structure and Function Studies
Share to Gastrointestinal motility and disorders
Share to Inflammatory Bowel Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30302792
DOI: 10.1002/jcb.27742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA‐21 increases the expression level of occludin through regulating ROCK1 in prevention of intestinal barrier dysfunctionPMID 30302792Read ↗

MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in ZebrafishSemantic proximity Read ↗

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospectiveSemantic proximity Read ↗

Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction BarrierSemantic proximity Read ↗

MicroRNA-21/PTEN/Akt axis in the fibrogenesis of biliary atresiaSemantic proximity Read ↗

MicroRNA-21 in the pathogenesis of acute kidney injurySemantic proximity Read ↗

Turbot (Scophthalmus maximus L.) occludin gene performs the anti-inflammatory function in the intestine via the regulations by miR-140-3p in the NF-κB pathwaySemantic proximity Read ↗

Divergent influence of microRNA-21 deletion on murine colitis phenotypes.Semantic proximity Read ↗

A high cholesterol diet aggravates experimental colitis through SREBP2-modulated endocytosis and degradation of occludin and Zo-1 proteins.Semantic proximity Read ↗

MicroRNA-21 Regulates the Invasion and Metastasis in Cholangiocarcinoma and May Be a Potential Biomarker for Cancer PrognosisSemantic proximity Read ↗

Long noncoding RNA <i>SPRY4-IT1</i> regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteinsSemantic proximity Read ↗

MicroRNA-122a Regulates Zonulin by Targeting EGFR in Intestinal Epithelial DysfunctionSemantic proximity Read ↗

miR‑21 inhibits autophagy and promotes malignant development in the bladder cancer T24�cell lineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.