Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway.

PLoS genetics - 1 Apr 2018

Lažetić Vladimir, Joseph Braveen B, Bernazzani Sarina M, Fay David S

Abstract excerpt

Molting is an essential process in the nematode Caenorhabditis elegans during which the epidermal apical extracellular matrix, termed the cuticle, is detached and replaced at each larval stage. The conserved NIMA-related kinases NEKL-2/NEK8/NEK9 and NEKL-3/NEK6/NEK7, together with their ankyrin repeat partners, MLT-2/ANKS6, MLT-3/ANKS3, and MLT-4/INVS, are essential for normal molting. In nekl and mlt mutants,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to GTP-Binding Proteins

Share to Microscopy, Confocal

Share to Molting

Share to NIMA-Related Kinases

Share to Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 29608564
DOI: 10.1371/journal.pgen.1007313
PMCID: PMC5897031

Genes

CDC42
INVS
NEK6
NEK7
NEK8
NEK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway.PMID 29608564Read ↗

Conserved Ankyrin Repeat Proteins and Their NIMA Kinase Partners Regulate Extracellular Matrix Remodeling and Intracellular Trafficking in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.Semantic proximity Read ↗

A life cycle alteration can correct molting defects in Caenorhabditis elegans.Semantic proximity Read ↗

PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking.Semantic proximity Read ↗

ZEN-4/MKLP1 is required to polarize the foregut epithelium.Semantic proximity Read ↗

A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in <i>C. elegans</i>Semantic proximity Read ↗

Control of clathrin-mediated endocytosis by NIMA family kinases.Semantic proximity Read ↗

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.Semantic proximity Read ↗

PIKI-1, a class II phosphatidylinositol 3-kinase, functions in endocytic traffickingSemantic proximity Read ↗

Functional Genomic Analysis of C. elegans MoltingSemantic proximity Read ↗

TAT-1, a phosphatidylserine flippase, affects molting and regulates membrane trafficking in the epidermis of <i>C. elegans</i>Semantic proximity Read ↗

Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.