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The loss of SMG1 causes defects in quality control pathways in Physcomitrella patens.

Nucleic acids research - 20 Jun 2018

Lloyd James P B, Lang Daniel, Zimmer Andreas D, Causier Barry, Reski Ralf, Davies Brendan

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is important for RNA quality control and gene regulation in eukaryotes. NMD targets aberrant transcripts for decay and also directly influences the abundance of non-aberrant transcripts. In animals, the SMG1 kinase plays an essential role in NMD by phosphorylating the core NMD factor UPF1. Despite SMG1 being ubiquitous throughout the plant kingdom, little is known about its...

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3' Untranslated Regions
Bryopsida
DNA Damage
Gene Expression
Nonsense Mediated mRNA Decay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphotransferases

Unfolded Protein Response

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Open in PubMed Open full text

Identifiers

PMID: 29596649
DOI: 10.1093/nar/gky225
PMCID: PMC6009662

Genes

SMG1
UPF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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