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Mutation of Arabidopsis SME1 and Sm core assembly improves oxidative stress resilience.

Free radical biology & medicine - 1 May 2023

Willems Patrick, Van Ruyskensvelde Valerie, Maruta Takanori, Pottie Robin, Fernández-Fernández Álvaro D, Pauwels Jarne, Hannah Matthew A, Gevaert Kris, Van Breusegem Frank, Van der Kelen Katrien

Abstract excerpt

Alternative splicing is a key posttranscriptional gene regulatory process, acting in diverse adaptive and basal plant processes. Splicing of precursor-messenger RNA (pre-mRNA) is catalyzed by a dynamic ribonucleoprotein complex, designated the spliceosome. In a suppressor screen, we identified a nonsense mutation in the Smith (Sm) antigen protein SME1 to alleviate photorespiratory H2O2-dependent cell death in...

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PMID: 36870374
DOI: 10.1016/j.freeradbiomed.2023.02.025

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