Article
Aberrant growth and lethality of Arabidopsis deficient in nonsense-mediated RNA decay factors is caused by autoimmune-like response.
Nucleic acids research - 1 Jul 2012
Riehs-Kearnan Nina, Gloggnitzer Jiradet, Dekrout Bettina, Jonak Claudia, Riha Karel
Abstract excerpt
Nonsense-mediated RNA decay (NMD) is an evolutionarily conserved RNA quality control mechanism that eliminates transcripts containing nonsense mutations. NMD has also been shown to affect the expression of numerous genes, and inactivation of this pathway is lethal in higher eukaryotes. However, despite relatively detailed knowledge of the molecular basis of NMD, our understanding of its physiological functions is...
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