Article
USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells.
Nature communications - 28 Mar 2018
Padmanabhan Achuth, Candelaria Nicholes, Wong Kwong-Kwok, Nikolai Bryan C, Lonard David M, O'Malley Bert W, Richards JoAnne S
Abstract excerpt
Gain-of-function p53 mutants such as p53-R175H form stable aggregates that accumulate in cells and play important roles in cancer progression. Selective degradation of gain-of-function p53 mutants has emerged as a highly attractive therapeutic strategy to target cancer cells harboring specific p53 mutations. We identified a small molecule called MCB-613 to cause rapid ubiquitination, nuclear export, and...
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