Article
Ubiquitin-specific protease 7-mediated stabilization of discoidin domain receptor 1 drives progression of TP53-Mutant cancers.
The Journal of biological chemistry - 1 Sept 2025
Xue Yiying, Xiu Bing, Yang Muye, Zhang Yanwei, Yang Changpeng, Zhang Lele, Yan Yilv, Luo Xiu, Huang Yushan, Mei Husheng, Li Guiming, Zhou Lixin, Chen Yisa, Zhang Wenjun, Qian Changlin, Zhang Peng, Liu Juan, Liang Aibin, Zeng Yu, Yang Jing
Abstract excerpt
Receptor tyrosine kinase DDR1 (Discoidin Domain Receptor 1) interacts with the extracellular matrix (ECM) to promote tumor cell proliferation through its intracellular kinase activity, while its extracellular non-enzymatic domain creates a physical barrier for immune evasion. Although DDR1 inhibitors and antibodies have been developed, targeting DDR1 kinase activity alone cannot fully block the biological effects...
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