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Article

The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease.

Biology of the cell - 1 Jan 2016

Michaux Grégoire, Massey-Harroche Dominique, Nicolle Ophélie, Rabant Marion, Brousse Nicole, Goulet Olivier, Le Bivic André, Ruemmele Frank M

Abstract excerpt

BACKGROUND INFORMATION: Microvillus inclusion disease (MVID) is a genetic disorder affecting intestinal absorption. It is caused by mutations in MYO5B or syntaxin 3 (STX3) affecting apical membrane trafficking. Morphologically, MVID is characterised by a depletion of apical microvilli and the formation of microvillus inclusions inside the cells, suggesting a loss of polarity. To investigate this hypothesis, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26526116
DOI: 10.1111/boc.201500034

Genes

STX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease.PMID 26526116Read ↗

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Microvillus Inclusion Disease: A Genetic Defect Affecting Apical Membrane Protein Traffic in Intestinal EpitheliumSemantic proximity Read ↗

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Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.Semantic proximity Read ↗

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