Article
The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2018
Xu Wen, Song Fei, Wang Biao, Li Kesang, Tian Mi, Yu Min, Pan Xiaorong, Shi Bizhi, Liu Jianwen, Gu Jianren, Li Zonghai, Jiang Hua
Abstract excerpt
BACKGROUND/AIMS: Epidermal growth factor receptor variant III (EGFRvIII), the most frequent EGFR variant, is constitutively activated without binding to EGF and is correlated with a poor prognosis. CH12, a human-mouse chimeric monoclonal antibody, has been developed in our laboratory and selectively binds to overexpressed EGFR and EGFRvIII. A previous study had reported that EGFR could influence autophagic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.