Article

Plasmodium circumsporozoite protein enhances the efficacy of gefitinib in lung adenocarcinoma cells by inhibiting autophagy via proteasomal degradation of LC3B

2021-08-17

Abstract excerpt

<title>Abstract</title> <p>Background: Almost all patients with lung adenocarcinoma (LUAD) develop resistance to EGFR-TKIs, which limit the long-term clinical application of these agents. Accumulating evidence shows one of the main reasons for resistance to EGFR-TKIs is induction of autophagy in tumor cells. Our previous study found that circumsporozoite protein (CSP) in Plasmodium can suppress autophagy in host...

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Literature Corpus work: 50403827-6f2a-59af-9839-ca7b757095f6
DOI: 10.21203/rs.3.rs-779166/v1

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