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Article

Anti-Metastatic Activity of an Anti-EGFR Monoclonal Antibody against Metastatic Colorectal Cancer with KRAS p.G13D Mutation.

International journal of molecular sciences - 21 Aug 2020

Ohishi Tomokazu, Kato Yukinari, Kaneko Mika K, Ohba Shun-Ichi, Inoue Hiroyuki, Harakawa Akiko, Kawada Manabu

Abstract excerpt

The now clinically-used anti-epidermal growth factor receptor (EGFR) monoclonal antibodies have demonstrated significant efficacy only in patients with metastatic colorectal cancer (mCRC), with wild-type Kirsten rat sarcoma viral oncogene homolog (KRAS). However, no effective treatments for patients with mCRC with KRAS mutated tumors have been approved yet. Therefore, a new strategy for targeting mCRC with KRAS...

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Identifiers

PMID: 32839411
DOI: 10.3390/ijms21176037
PMCID: PMC7504481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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