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Article

EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

13 Dec 2013

Abstract excerpt

The epidermal growth factor receptor (EGFR) is amplified or mutated in various human epithelial tumors. Its expression and activation leads to cell proliferation, differentiation, and survival. Consistently, EGFR amplification or expression of EGFR variant 3 (EGFRvIII) is associated with resistance to conventional cancer therapy through activation of pro-survival signaling and DNA-repair mechanisms. EGFR...

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PMID: 24335351
DOI: 10.4161/cc.27518

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