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Article

Autophagosome-mediated EGFR down-regulation induced by the CK2 inhibitor enhances the efficacy of EGFR-TKI on EGFR-mutant lung cancer cells with resistance by T790M.

PloS one - 1 Jan 2014

So Kwang Sup, Kim Cheol Hyeon, Rho Jin Kyung, Kim Sun Ye, Choi Yun Jung, Song Joon Seon, Kim Woo Sung, Choi Chang Min, Chun Young Jin, Lee Jae Cheol

Abstract excerpt

Protein kinase CK2 has diverse functions promoting and maintaining cancer phenotypes. We investigated the effect of CK2 inhibition in lung cancer cells with T790M-mediated resistance to the EGFR-TK inhibitor. Resistant sublines of PC-9 to gefitinib (PC-9/GR) and erlotinib (PC-9/ER) were establish...

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Identifiers

PMID: 25486409
DOI: 10.1371/journal.pone.0114000
PMCID: PMC4259313

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EGFR

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25486409-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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