Article
A Germline Mutation in the BRCA1 3’UTR Variant Predicts Susceptibility to Breast Cancer in a Saudi Arabian Population
Asian Pacific journal of cancer prevention : APJCP - 27 Mar 2018
Mir Rashid, Javid Jamsheed, Al Balawi Ibrahim Abdullah, Alkharsah Khaled R., Hadi Maha Abdel, Rahman Mostafa Abdel, Hamoud Ebtesam, Al Alawi Yousef, Al Zahrani Attiya Bin Mohammad, Abu-Duhier F M
Abstract excerpt
Purpose: The impact of the BRCA1-3’UTR-variant on BRCA1 gene expression and altered responses to external stimuli was previously tested in vitro using a luciferase reporter assay. Its ability to predict breast cancer risk in women was also assessed but the conclusions were inconsistent. The present study concerns the relationship between the BRCA1-3’UTR germline variant rs8176318G>T and susceptibility to Breast...
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