Article
Cooption of an appendage-patterning gene cassette in the head segmentation of arachnids.
Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2018
Setton Emily V W, Sharma Prashant P
Abstract excerpt
The jointed appendages of arthropods have facilitated the spectacular diversity and success of this phylum. Key to the regulation of appendage outgrowth is the Krüppel-like factor (KLF)/specificity protein (Sp) family of zinc finger transcription factors. In the fruit fly, Drosophila melanogaster, the Sp6-9 homolog is activated by Wnt-1/wingless (wg) and establishes ventral appendage (leg) fate. Subsequently,...
Topics
- Animals
- Arachnida
- Biological Evolution
- Body Patterning
- Evolution, Molecular
- Extremities
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Kruppel-Like Transcription Factors
- Phenotype
- RNA Interference
- Spiders
- Transcription Factors
- Wnt1 Protein
- Zinc Fingers