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Article

Cooption of an appendage-patterning gene cassette in the head segmentation of arachnids.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2018

Setton Emily V W, Sharma Prashant P

Abstract excerpt

The jointed appendages of arthropods have facilitated the spectacular diversity and success of this phylum. Key to the regulation of appendage outgrowth is the Krüppel-like factor (KLF)/specificity protein (Sp) family of zinc finger transcription factors. In the fruit fly, Drosophila melanogaster, the Sp6-9 homolog is activated by Wnt-1/wingless (wg) and establishes ventral appendage (leg) fate. Subsequently,...

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Identifiers

PMID: 29581309
DOI: 10.1073/pnas.1720193115
PMCID: PMC5899462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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