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Article

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

26 Mar 2018

Abstract excerpt

Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression is universal, and tumors with AR-independent resistance mechanisms appear to be increasing in frequency. Consequently, there is an urgent need to develop new treatments targeting molecular pathways enriched in lethal prostate cancer. Lysine-specific...

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PMID: 29581250
DOI: 10.1073/pnas.1719168115

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