Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.

Journal of cellular and molecular medicine - 1 Jun 2018

Hsu Ping-Chih, Miao Jinbai, Huang Zhen, Yang Yi-Lin, Xu Zhidong, You Joanna, Dai Yuyuan, Yeh Che-Chung, Chan Geraldine, Liu Shu, Urisman Anatoly, Yang Cheng-Ta, Jablons David M, You Liang

Abstract excerpt

Yes-associated protein (YAP) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine model. We found that metastatic NSCLC cell lines H2030-BrM3(K-rasG12C mutation) and PC9-BrM3 (EGFRΔexon19 mutation) had a significantly decreased p-YAP(S127)/YAP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Connective Tissue Growth Factor

Share to Phosphoproteins

Share to RNA, Small Interfering

Share to Xenograft Model Antitumor Assays

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29575527
DOI: 10.1111/jcmm.13582
PMCID: PMC5980132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.PMID 29575527Read ↗

Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung CancerSemantic proximity Read ↗

YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis.Semantic proximity Read ↗

STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activationSemantic proximity Read ↗

Serum sphingosine-1-phosphate levels are associated with brain metastasis in EGFR-mutant lung adenocarcinoma.Semantic proximity Read ↗

YAP1 promotes multidrug resistance of small cell lung cancer by CD74‐related signaling pathwaysSemantic proximity Read ↗

Bosutinib inhibits migration and invasion via ACK1 in KRAS mutant non-small cell lung cancer.Semantic proximity Read ↗

A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop.Semantic proximity Read ↗

Cell adhesion molecule 2 (CADM2) promotes brain metastasis by inducing epithelial-mesenchymal transition (EMT) in human non-small cell lung cancerSemantic proximity Read ↗

YAP mediates resistance to EGF-induced apoptosis in EGFR-mutated non-small cell lung cancer cells.Semantic proximity Read ↗

Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic propertiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.