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Article

YAP mediates resistance to EGF-induced apoptosis in EGFR-mutated non-small cell lung cancer cells.

Biochemical and biophysical research communications - 12 Nov 2023

Nakajima Maako, Tanaka Kentaro, Yoneshima Yasuto, Yamashita Sho, Shibahara Daisuke, Iwama Eiji, Okamoto Isamu

Abstract excerpt

Mechanisms underlying the growth and survival of non-small cell lung cancer (NSCLC) cells positive for activating mutations of the epidermal growth factor receptor gene (EGFR) have remained unclear. We here examined the functional relation between such mutant forms of EGFR and Yes-associated protein (YAP), a transcriptional coactivator of the Hippo signaling pathway that regulates cell proliferation and survival....

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Source

Identifiers

PMID: 37774569
DOI: 10.1016/j.bbrc.2023.09.067

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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