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Article

Heterozygous α1-antitrypsin Z allele mutation in presumed healthy donor livers used for transplantation.

European journal of gastroenterology & hepatology - 1 Nov 2013

Roelandt Philip, Dobbels Pieter, Komuta Mina, Corveleyn Anniek, Emonds Marie-Paule, Roskams Tania, Aerts Raymond, Monbaliu Diethard, Libbrecht Louis, Laleman Wim, Verslype Chris, Van Steenbergen Werner, van der Merwe Schalk, Pirenne Jacques, Nevens Frederik, Cassiman David

Abstract excerpt

OBJECTIVES: The Z allele (Glu342Lys) in α1-antitrypsin (AAT) deficiency is a combined deficiency and dysfunctional allele. Carrying one Z allele induces a risk of a more aggressive evolution in patients with a chronic liver disease. As most of the carriers of Z allele do not have overt liver dise...

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PMID: 23660934
DOI: 10.1097/MEG.0b013e32836171c4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23660934-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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