Article
HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis.
Frontiers in immunology - 1 Jan 2024
Peris Sempere Vicente, Luo Guo, Muñiz-Castrillo Sergio, Pinto Anne-Laurie, Picard Géraldine, Rogemond Véronique, Titulaer Maarten J, Finke Carsten, Leypoldt Frank, Kuhlenbäumer Gregor, Jones Hannah F, Dale Russell C, Binks Sophie, Irani Sarosh R, Bastiaansen Anna E, de Vries Juna M, de Bruijn Marienke A A M, Roelen Dave L, Kim Tae-Joon, Chu Kon, Lee Soon-Tae, Kanbayashi Takamichi, Pollock Nicholas R, Kichula Katherine M, Mumme-Monheit Abigail, Honnorat Jérôme, Norman Paul J, Mignot Emmanuel
Abstract excerpt
Introduction: Genetic predisposition to autoimmune encephalitis with antibodies against N-methyl-D-aspartate receptor (NMDAR) is poorly understood. Given the diversity of associated environmental factors (tumors, infections), we hypothesized that human leukocyte antigen (HLA) and killer-cell immunoglobulin-like receptors (KIR), two extremely polymorphic gene complexes key to the immune system, might be relevant...
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