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Article

Structural basis of DUX4/IGH-driven transactivation.

Leukemia - 1 Jun 2018

Dong Xue, Zhang Weina, Wu Haiyan, Huang Jinyan, Zhang Ming, Wang Pengran, Zhang Hao, Chen Zhu, Chen Sai-Juan, Meng Guoyu

Abstract excerpt

Oncogenic fusions are major drivers in leukemogenesis and may serve as potent targets for treatment. DUX4/IGHs have been shown to trigger the abnormal expression of ERGalt through binding to DUX4-Responsive-Element (DRE), which leads to B-cell differentiation arrest and a full-fledged B-ALL. Here, we determined the crystal structures of Apo- and DNADRE-bound DUX4HD2 and revealed a clamp-like transactivation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeodomain Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 29572508
DOI: 10.1038/s41375-018-0093-1
PMCID: PMC5990521

Genes

DUX4
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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