Article
Biochemical characterization of the Helicobacter pylori Cag Type 4 Secretion System protein CagN and its interaction partner CagM.
International journal of medical microbiology : IJMM - 1 Jun 2018
Bats Simon H, Bergé Célia, Coombs Nina, Terradot Laurent, Josenhans Christine
Abstract excerpt
Highly virulent Helicobacter pylori strains contain the cag pathogenicity island (cagPAI). It codes for about 30 proteins forming a type IV secretion system (T4SS) which translocates the pro-inflammatory protein CagA into epithelial host cells. While CagA and various other Cag proteins have been extensively studied, several cagPAI proteins are poorly characterized or of unknown function. CagN (HP0538) is of...
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