Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long-Term Treatment of Tamoxifen and Raloxifene Alleviates Dystrophic Phenotype and Enhances Muscle Functions of FKRP Dystroglycanopathy.

The American journal of pathology - 1 Apr 2018

Wu Bo, Shah Sapana N, Lu Peijuan, Bollinger Lauren E, Blaeser Anthony, Sparks Susan, Harper Amy D, Lu Qi L

Abstract excerpt

The third most common form of limb-girdle muscular dystrophies is caused by mutations of the Fukutin-related protein (FKRP) gene, with no effective therapy available. Selective estrogen receptor modulators, tamoxifen and raloxifene, have been widely used for human conditions for their anti-inflammatory, antifibrosis, prevention of bone loss, and muscle building effects (essential features for muscular dystrophy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dystroglycans
Share to Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscles

Share to Muscular Dystrophy, Animal

Share to Pentosyltransferases

Share to Selective Estrogen Receptor Modulators

Share to Tamoxifen

Share to Transferases

Source

Identifiers

PMID: 29571322
DOI: 10.1016/j.ajpath.2017.12.011

Genes

FKRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long-Term Treatment of Tamoxifen and Raloxifene Alleviates Dystrophic Phenotype and Enhances Muscle Functions of FKRP Dystroglycanopathy.PMID 29571322Read ↗

Glucocorticoid Steroid and Alendronate Treatment Alleviates Dystrophic Phenotype with Enhanced Functional Glycosylation of α-Dystroglycan in Mouse Model of Limb-Girdle Muscular Dystrophy with FKRPP448L Mutation.Semantic proximity Read ↗

Sexually dimorphic skeletal muscle and cardiac dysfunction in a mouse model of limb girdle muscular dystrophy 2i.Semantic proximity Read ↗

Overactive PDGFRα and PDGFRβ promote distinct yet overlapping phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving drastic muscle growthSemantic proximity Read ↗

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibitionSemantic proximity Read ↗

Overactive PDGFRα and PDGFRβ promote distinct phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving muscle growth.Semantic proximity Read ↗

Tamoxifen in Duchenne muscular dystrophy (TAMDMD): study protocol for a multicenter, randomized, placebo-controlled, double-blind phase 3 trialSemantic proximity Read ↗

An integrated study of hormone-related sarcopenia for modeling and comparative transcriptome in ratsSemantic proximity Read ↗

Use of HSALR female mice as a model for the study of myotonic dystrophy type I.Semantic proximity Read ↗

Progressive Dystrophic Pathology in Diaphragm and Impairment of Cardiac Function in FKRP P448L Mutant Mice.Semantic proximity Read ↗

Fibroblast growth factor-21 induces skeletal muscle atrophy and increases plasma amino acids in female mice: a potential role for glucocorticoidsSemantic proximity Read ↗

Corticortophin releasing factor 2 receptor agonist treatment significantly slows disease progression in mdx mice.Semantic proximity Read ↗

Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.